EntransterTM-in vivo動物體內轉染試劑可將小片斷RNA如siRNA，miRNA，mimic、inhibitor轉染到動物體內，在動物體內進行RNA干擾等實驗。
EntransterTM-in vivo試劑不是病毒，改變了病毒轉染方法復雜、周期長、不穩定、花費大、安全性等諸多問題。EntransterTM-in vivo轉染效率高，方法簡單，無需病毒包裝，直接將RNA送入目的細胞的細胞核中表達。
EntransterTM-in vivo，非脂質體，采用納米技術合成，通過保護和濃縮核酸，避免核酸被體液破壞，并通過物理作用將核酸富集在細胞表面，增強核酸進入細胞組織，從而產生作用。EntransterTM-in vivo能耐受體內復雜的環境，不產生免疫反應。
應用范圍
專用于動物體內轉染，可直接轉染RNA到動物體內進行：
● 基因治療的動物體內研究
● RNA干擾的動物體內研究
● 蛋白功能的動物體內研究
主要特點
最快3天可以得到結果，核酸+轉染試劑，注射動物，完成轉染。
● 肝、腎、心、肺，血液系統，神經系統，生殖系統，皮膚…成功應用。
● 可方便、快捷更換不同的小片斷RNA進行動物試驗。
● 方法先進，拋棄病毒，眾多實驗室應用，穩定可靠。
● 比使用病毒節省90%以上費用，時間縮短到3天！
應用本產品文獻
1.Nature Communications. 2019 Sep 20. Inactivation of NF-κB2 (p52) restrains hepatic glucagon response via preserving PDE4B induction.(IF: 11.878.)（肝胰高血糖素反應研究）
2.Biochemical and Biophysical Research Communications. 2019 Sep 13. Activation of Dusp14 protects against osteoclast generation and bone loss by regulating AMPKα-dependent manner.（破骨細胞生成和骨丟失研究）
3.Cell Death & Disease. 2019 Sep 11. Transforming growth factor (TGF)-β1-induced miR-133a inhibits myofibroblast differentiation and pulmonary fibrosis.(IF: 5.959.)（肌成纖維細胞分化和肺纖維化研究）
4.Life Sciences. 2019 Aug 30. Effects of MFHAS1 on cognitive impairment and dendritic pathology in the hippocampus of septic rats.（mfhas1對膿毒癥大鼠認知功能障礙及海馬樹突病理的影響研究）
5.Molecular Therapy-Nucleic Acids. 2019 Aug 12. lnc-3215
Suppression Leads to Calcium Overload in Selenium Deficiency-Induced Chicken Heart Lesion via the lnc-3215-miR-1594-TNN2 Pathway.(IF: 5.919.)（lnc-3215與低硒雞心臟損傷鈣超載研究）
6.Journal of Cancer. 2019 Jul 8. Regulation of response to radiotherapy by β-arrestin1 in Non-small cell lung cancer.（非小細胞肺癌研究）
7.Cell Death & Disease. 2019 Jun 5. Mechanism of Snhg8/miR-384/Hoxa13/FAM3A axis regulating neuronal apoptosis in ischemic mice model.(IF: 5.959.)（缺血小鼠神經元凋亡調控研究）
8.EBioMedicine. 2019 May 23. MicroRNA-200b is downregulated and suppresses metastasis by targeting LAMA4 in renal cell carcinoma.(IF: 6.68.)（microrna-200b與腎癌轉移研究）
9.Translational Stroke Research. 2019 May 10. RIP3 participates in early brain injury after experimental subarachnoid hemorrhage in rats by inducing necroptosis.(IF: 5.16.)（RIP3與大鼠實驗性蛛網膜下腔出血后早期腦損傷研究）
10.Cellular & Molecular Immunology. 2019 May 7. Metabolic modulation of acetaminophen-induced hepatotoxicity by osteopontin.(IF: 8.213.)（骨橋蛋白代謝對乙酰氨基酚肝毒性的調節作用研究）
11.Biochemical and Biophysical Research Communications. 2019 May 3. FBXW5 reduction alleviates spinal cord injury (SCI) by blocking microglia activity: A mechanism involving p38 and JNK.（FBXW5與脊髓損傷研究）
12.Neuroscience. 2019 Apr 29. NEMO-binding domain peptides alleviate perihematomal inflammation injury after experimental intracerebral hemorrhage.（實驗性腦出血后血周炎癥損傷研究）
13.Redox Biology. 2019 Apr 17. Advanced oxidation protein products induce G1 phase arrest in intestinal epithelial cells via a RAGE/CD36-JNK-p27kip1 mediated pathway.(IF:7.793.)（腸上皮細胞G1期阻滯研究）
14.Bioconjugate Chemistry. 2019 Apr 16. Dextran-Conjugated Caged siRNA Nanoparticles for Photochemical Regulation of RNAi-Induced Gene Silencing in Cells and Mice.（籠狀siRNA和光化學調控RNAi誘導的小鼠基因沉默研究）
15.Osteoarthritis and Cartilage. 2019 Feb 2. Clock mutant promotes osteoarthritis by inhibiting the acetylation of NFκB.(IF: 5.454.)（Clock突變體和骨關節炎研究）
16.Experimental Neurology. 2019 Jan 30. GATA-4 regulates neuronal apoptosis after intracerebral hemorrhage via the NF-κB/Bax/Caspase-3 pathway both in vivo and in vitro.(IF: 4.483.)（GATA-4調節腦出血后神經元凋亡）
17.Brain, Behavior, and Immunity. 2019 Jan 24. MicroRNA-146a protects against cognitive decline induced by surgical trauma by suppressing hippocampal neuroinflammation in mice.(IF: 6.306.)（小鼠手術創傷引起的認知功能下降研究）
18.Journal of Neuroinflammation. 2019 Jan 15. Mesenchymal stem cells alleviate the early brain injury of subarachnoid hemorrhage partly by suppression of Notch1-dependent neuroinflammation: involvement of Botch.(IF: 5.193.)（間充質干細胞減輕蛛網膜下腔出血早期腦損傷）
19.Journal of Cellular Physiology. 2019 Jan 17. A novel long noncoding RNA AK016739 inhibits osteoblast differentiation and bone formation.（LncRNA AK016739抑制成骨細胞分化和骨形成）
20.Journal of Experimental & Clinical Cancer Research. 2019 Jan 10. Fusobacterium nucleatum promotes chemoresistance to 5-fluorouracil by upregulation of BIRC3 expression in colorectal cancer.(IF: 6.217.)（有核梭桿菌與直腸癌中5-氟尿嘧啶的化療抗性）
21.Free Radical Biology and Medicine. 2018 Dec 30. Loss of RIP3 initiates annihilation of high-fat diet initialized nonalcoholic hepatosteatosis: A mechanism involving Toll-like receptor 4 and oxidative stress.(IF: 6.020.)（RIP3的缺失和非酒精性脂肪肝疾病研究）
22.British Journal of Pharmacology. 2018 Dec 18. Mitochondrial protective effect of neferine through the modulation of nuclear factor erythroid 2-related factor 2 signalling in ischaemic stroke.(IF: 6.810.)（荷花堿通過調節nrf2信號對缺血性卒中線粒體的保護作用 ）
23.Experimental Neurology. 2018 Dec 5. Significant changes in circular RNA in the mouse cerebral cortex around an injury site after traumatic brain injury.(IF: 4.483.)（大鼠腦外傷后大腦皮層環狀RNA變化研究）
24.Biochemical and Biophysical Research Communications. 2018 Dec 5. Blocking of tripartite motif 8 protects against lipopolysaccharide (LPS)-induced acute lung injury by regulating AMPKα activity.（脂多糖（LPS）誘導的急性肺損傷）
25.Journal of Cellular Biochemistry. 2018 Dec 5. miR‐202 modulates the progression of neuropathic pain through targeting RAP1A.（Mir-202通過靶向RAP1A調節神經性疼痛的進展 ）
26.Developmental & Comparative Immunology. 2018 Nov 11. Global profiling of megalocytivirus-induced proteins in tongue sole (Cynoglossus semilaevis) spleen identifies cellular processes essential to viral infection.（半滑舌鰨脾臟巨核細胞病毒誘導蛋白）
27.Journal of Cellular Physiology. 2018 Oct 14. MiR‐208b regulates cell cycle and promotes skeletal muscle cell proliferation by targeting CDKN1A.（mir‐208b通過靶向cdkn1a調節細胞周期并促進骨骼肌細胞增殖）
28.Journal of Cellular Physiology. 2018 Mar 25.miR‐34b‐5p inhibition attenuates lung inflammation and apoptosis in an LPS‐induced acute lung injury mouse model by targeting progranulin.（miR‐34b‐5p與急性肺損傷研究）
29.Bone. 2018 Mar 16. Overexpression of DNMT1 leads to hypermethylation of H19 promoter and inhibition of Erk signaling pathway in disuse osteoporosis.（DNMT1過表達和廢用性骨質疏松研究）
30.Molecular Imaging and Biology. 2018 Mar 12. Bioluminescence Imaging for Monitoring miR-200c Expression in Breast Cancer Cells and its Effects on Epithelial-Mesenchymal Transition Progress in Living Animals.（mir-200c在乳腺癌細胞上皮間質轉化中作用研究）
31.Canadian Journal of Physiology and Pharmacology. 2018 Mar 5. The role of microRNA-146a in regulating the expression of IRAK1 in cerebral ischemia-reperfusion injury.（microRNA-146a在調控腦缺血-再灌注損傷中IRAK1表達的作用研究）
32.Mol Ther Nucleic Acids. 2018 Mar 2. Circular siRNAs for Reducing Off-Target Effects and Enhancing Long-Term Gene Silencing in Cells and Mice.（環狀siRNA與基因脫靶效應研究）
33.CNS Neuroscience & Therapeutics. 2018 Feb 27. Inhibition of Lats1/p‐YAP1 pathway mitigates neuronal apoptosis and neurological deficits in a rat model of traumatic brain injury.（大鼠創傷性腦損傷模型中神經元凋亡和神經功能障礙研究）
34.Biomaterials. 2018 Feb 24. Hypoxia-inducible Factor-1α directs renal regeneration induced by decellularized scaffolds.（DNA甲基轉移酶3a與乙型肝炎病毒研究）
35.Neuroscience. 2018 Feb 5. Long Non-coding RNA BC168687 is Involved in TRPV1-mediated Diabetic Neuropathic Pain in Rats.（LncRNA BC168687參與TRPV1受體介導的糖尿病大鼠神經病理性疼痛）
36.Front. Cell. Neurosci. 2018 Jan 11.Neuroprotection Exerted by Netrin-1 and Kinesin Motor KIF1A in Secondary Brain Injury following Experimental Intracerebral Hemorrhage in Rats.（神經軸突導向因子netrin-1與大鼠實驗性腦出血后繼發性腦損傷中的神經保護作用研究）
37.Cell Death & Disease. 2018 Jan 9.miRNA-3473b contributes to neuroinflammation following cerebral ischemia.（miRNA-3473b導致腦缺血后神經炎癥）
38.eCAM. 2018 Jan 9. The Protective Effect of Total Flavones from Rhododendron simsii Planch. on Myocardial Ischemia/Reperfusion Injury and Its Underlying Mechanism.（杜鵑花總黃酮對心肌缺血再灌注損傷保護作用）
39.Exp Cell Res. 2017 Dec 15. Erythropoietin ameliorates early brain injury after subarachnoid haemorrhage by modulating microglia polarization via the EPOR/JAK2-STAT3 pathway.（促紅細胞生成素與蛛網膜下腔出血早期腦損傷研究）
40.Cell Death & Disease. 2017 Dec 13.Long non-coding RNA MEG3 functions as a competing endogenous RNA to regulate ischemic neuronal death by targeting miR-21/PDCD4 signaling pathway.（LncRNA MEG3與缺血性神經元死亡研究）
41.Journal of Cellular Biochemistry. 2017 Dec 12. Circular siRNAs for Reducing Off-Target Effects and Enhancing Long-Term Gene Silencing in Cells and Mice.（環狀siRNA與基因脫靶效應研究）
42.Journal of Cellular Biochemistry. 2017 Dec 12. Effects of Microrna‐93 on Mouse Cardiac Microvascular Endothelial Cells Injury and Inflammatory Response by Mediating SPP1 Through the NF‐ΚB Pathway.（microRNA‐93與小鼠心肌微血管內皮細胞損傷研究）
43.Neurobiology of Disease. 2017 Dec 2. Critical role for Annexin A7 in secondary brain injury mediated by its phosphorylation after experimental intracerebral hemorrhage in rats.（膜聯蛋白A7在大鼠繼發性腦損傷中的作用研究）
44.Purinergic Signalling. 2017 Nov 20. P2Y12 receptor upregulation in satellite glial cells is involved in neuropathic pain induced by HIV glycoprotein 120 and 2′,3′-dideoxycytidine.（衛星膠質細胞中P2Y12受體上調與神經性疼痛研究）
45.Chmeical Science. 2017 Oct 19. Caged circular siRNAs for photomodulation of gene expression in cells and mice .（環狀RNA與基因表達光調控）
46.Oncotarget. 2017 May 30. MicroRNA-423-5p facilitates hypoxia/reoxygenation-induced apoptosis in renal proximal tubular epithelial cells by targeting GSTM1 via endoplasmic reticulum stress.(IF:5.168.)（腎小管上皮細胞凋亡）
47.Biochemical and Biophysical Research Communications. 2017 May 25. Targeting long non-coding RNA ASBEL with oligonucleotide antagonist for breast cancer therapy.（長鏈非編碼RNA與乳腺癌治療）
48.Journal of Neurochemistry. 2017 May 24. TRAF6 participates in early brain injury after subarachnoid hemorrhage in rats through inhibiting autophagy and promoting oxidative stress.（大鼠蛛網膜下腔出血與早期腦損傷）
49.Clin Exp Pharmacol Physiol. 2017 May 19. Limb remote ischaemic postconditioning-induced elevation of fibulin-5 confers neuroprotection to rats with cerebral ischaemia/reperfusion injury: Activation of the AKT pathway.（AKT通路與大鼠大腦局部缺血/再灌注損傷）
50.Neurological Research. 2017 May 1. The 15-LO-1/15-HETE system promotes angiogenesis by upregulating VEGF in ischemic brains. （15-LO-1siRNA通過在小鼠缺血性腦中上調VEGF來促進血管生成）
51.Blood. 2017 Apr 27. Osteoblasts support megakaryopoiesis through production of interleukin 9.(IF: 11.841.)（成骨細胞與白介素9研究）
52.EBioMedicine. 2017 Apr 11. Fluvastatin Prevents Lung Adenocarcinoma Bone Metastasis by Triggering Autophagy.（siRNA與小鼠肺腺癌骨轉移研究）
53.Cellular and Molecular Neurobiology. 2017 Feb 25. Regulation of Sirtuin 3-Mediated Deacetylation of Cyclophilin D Attenuated Cognitive Dysfunction Induced by Sepsis-Associated Encephalopathy in Mice. （siRNA側腦室注射研究小鼠膿毒癥相關腦病引起的認知功能障礙）
54.Mediators Inflamm. 2017 Feb 15. Involvement of Toll Like Receptor 2 Signaling in Secondary Injury during Experimental Diffuse Axonal Injury in Rats. （大鼠實驗性彌漫性軸索損傷）
55.Plos one, 2016 March 9. MiR-3162-3p Is a Novel MicroRNA That Exacerbates Asthma by Regulating β-Catenin.( MiR-3162-3p通過調控β-鏈蛋白從而加劇哮喘的發作)
56.International Journal of Molecular Medicine. 2016 May 31. miR-1 suppresses the growth of esophageal squamous cell carcinoma in vivo and in vitro through the downregulation of MET, cyclin D1 and CDK4 expression.（miR-1通過MET，細胞周期蛋白D1和CDK4表達的下調在體內和體外抑制食管鱗狀細胞癌的生長）
57.Arthritis&Rheumatol, 2016 Apr. In Vivo Therapeutic Success of MicroRNA‐155 (miR‐155) Antagomir in a Mouse Model of Lupus Alveolar Hemorrhage.(IF: 6.009.)(miR‐155拮抗劑體內成功治療狼瘡性肺泡出血模型的小鼠）
58.Canadian Journal of Physiology and Pharmacology. 2016 Nov 24. miR-29b promotes skin wound healing and reduces excessive scar formation by inhibition of TGF-β1/Smad/CTGF signaling pathway.（miR-29b通過抑制TGF-β1/ Smad / CTGF信號通路促進皮膚傷口愈合并減少過度瘢痕形成）
59.Scientific Reports. 2016 Sep 19. Transient receptor potential channel 1/4 reduces subarachnoid hemorrhage-induced early brain injury in rats via calcineurin-mediated NMDAR and NFAT dephosphorylation.(IF: 5.228.)（蛛網膜下腔出血和小鼠大腦損傷）
60.Am J Cancer Res. 2016 Jun 1. BMPR2-pSMAD1/5 signaling pathway regulates RUNX2 expression and impacts the progression of dedifferentiated chondrosarcoma.（BMPR2-pSMAD1 / 5信號通路調節RUNX2表達，并影響去分化軟骨肉瘤的進展）
61.Scientific Reports. 2016 Jun 29. Molecular characterization of woodchuck IFI16 and AIM2 and their expression in woodchucks infected with woodchuck hepatitis virus (WHV).(IF: 5.228.)（土撥鼠肝炎病毒感染的土撥鼠中IFI16和AIM2的分子鑒定及表達）
62.Oncotarget. 2016 May 11 . Bmi1 inhibition enhances the sensitivity of pancreatic cancer cells to gemcitabine.（抑制Bmi1可以增強胰腺癌細胞對gemcitabine的敏感性）
63.Oncotarget. 2016 Sep 24. Fine-tuning the expression of microRNA-155 controls acetaminophen-induced liver inflammation.（miR-155與乙酰氨基酚誘導的肝臟炎癥）
64.Experimental and Therapeutic Medicine . 2016 Jun 7. Role of miR-145 in chronic constriction injury in rats.（miR-145在大鼠慢性壓迫性損傷中的作用）
65.Oncotarget. 2016 Sep 26. HMGB2 regulates satellite-cell-mediated skeletal muscle regeneration through IGF2BP2.(IF: 5.168.)（HMGB2通過IGF2BP2調節衛星細胞介導的骨骼肌再生）
66.Journal of Bone and Mineral Research. 2016 Sep 26. TET3 Mediates Alterations in the Epigenetic Marker 5hmC and Akt Pathway in Steroid-Associated Osteonecrosis.(IF: 5.622.)（TET3介導類固醇相關性骨壞死中表觀遺傳標記5hmC和Akt途徑的改變）
67.Journal of Bone and Mineral Research. 2016 Nov 24. The Circadian Gene Clock Regulates Bone Formation via PDIA3.(IF: 5.622.)（晝夜節律基因時鐘通過PDIA3調節骨形成）
68.Experimental Eye Research. 2016 Oct. CD25 siRNA induces Treg/Th1 cytokine expression in rat corneal transplantation models.（CD25 siRNA誘導大鼠角膜移植模型中的Treg / Th1細胞因子表達）
69.Chinese Journal of Biochemistry and Molecular Biology. 2016 Jun 9. 過表達微小RNA miR-125b抑制肝癌細胞上皮-間質轉換及促進細胞凋亡
70.Genetic Testing and Molecular Biomarkers. 2016 Nov 1. Upregulation of miR-98 Inhibits Apoptosis in Cartilage Cells in Osteoarthritis.（miR-98上調可抑制骨關節炎中軟骨細胞凋亡）
71.Int J Clin Exp Patho, 2016, March 15. Regulation of ZNF580 in pathogenesis of ischemic cerebrovascular disease accompanied with upregulation of Smad2 and ADNP( 在伴隨著Smad2和ADNP上調缺血性腦血管病的發病機制中ZNF580的調節）
72.Med Sci Monit. 2016 Apr 7. MiR-206 Attenuates Denervation-Induced Skeletal Muscle Atrophy in Rats Through Regulation of Satellite Cell Differentiation via TGF-β1, Smad3, and HDAC4 Signaling.(miR-206通過TGF-β1、Smad3和HDAC4信號調控衛星細胞分化進而減弱大鼠骨骼肌萎縮）
73.J Cardiovasc Pharmacol Ther. 2016 Feb 4. The PTEN/Akt Signaling Pathway Mediates Myocardial Apoptosis in Swine After Coronary Microembolization(PTEN / Akt信號通路介導豬冠狀動脈微栓塞后心肌細胞凋亡)
74.J Exp Clin Cancer Res. 2016 Mar 11. Inhibition of SOX2 induces cell apoptosis and G1/S arrest in Ewing’s sarcoma through the PI3K/Akt pathway(PI3K/Akt 信號通路中SOX2基因的抑制可以誘導尤文肉瘤細胞凋亡及G1/S的捕捉）
75. Cell Physiol Biochem. 2016 feb. Upregulation of Long Non-Coding RNA PlncRNA-1 Promotes Metastasis and Induces Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma.(長鏈非編碼RNA PlncRNA-1的上調可以促進并誘導肝癌細胞上皮間質之間轉化）
76. Eur J Pharmacol. 2016 Jan 15. Effect of vasopressin on Na(+)-K(+)-2Cl(-) cotransporter (NKCC) and the signaling mechanisms on the murine late distal colon.（抗利尿激素對Na(+)-K(+)-2Cl(-) 協同轉運蛋白的作用以及對小鼠遠端結腸的信號機制）
77. Cell Physiol Biochem. 2016 Jan Atorvastatin Inhibits Myocardial Apoptosis in a Swine Model of Coronary Microembolization by Regulating PTEN/PI3K/Akt Signaling Pathway.（阿托伐他汀通過調節PTEN/PI3K/Akt信號通路抑制冠狀動脈微栓塞模型豬心肌細胞凋亡）
78. Arthritis&Rheumatol. 2016 Apr 25 .MiR-130b ameliorates murine lupus nephritis through targeting type I interferon pathway on resident renal cells.(IF:6.009 )（miR-130b通過靶向I型干擾素通路作用于腎臟固有細胞從而改善小鼠狼瘡性腎）
79. J Cardiovasc Pharmacol Ther. 2016 Mar. Coronary Microembolization Induces Cardiomyocyte Apoptosis in Swine by Activating the LOX-1-Dependent Mitochondrial Pathway and Caspase-8-Dependent Pathway.（冠狀動脈微栓塞可通過激活lox-1依賴型線粒體通路和半胱天冬酶-8依賴型通路引起豬的心肌細胞凋亡）
80. Mol Brain. 2016 Apr 23. LncRNA NONRATT021972 siRNA regulates neuropathic pain behaviors in type 2 diabetic rats through the P2X7 receptor in dorsal root ganglia.（長鏈非編碼RNA NONRATT021972 干擾RNA可通過作用于背根神經節P2X7受體調節2型糖尿病大鼠神經性疼痛的行為）
81. Cell Death Dis. 2016 Mar 24. Inhibition of glycogen synthase kinase 3β promotes autophagy to protect mice from acute liver failure mediated by peroxisome proliferator-activated receptor α.（抑制糖原合成酶激酶3β可以促進自噬以保護小鼠免受由過氧化物酶體增殖物激活受體介導的急性肝衰竭的的損害）
82. Int J Biochem Cell Biol. 2016 Mar 18 Inhibitory effects of omega-3 fatty acids on early brain injury after subarachnoid hemorrhage in rats: Possible involvement of G protein-coupled receptor 120/β-arrestin2/TGF-βactivated kinase-1 binding protein-1 signaling pathway.（ω-3脂肪酸對大鼠蛛網膜下腔出血早期腦損傷的抑制作用）
83.Endocrinology. 2015 Sep 11. Rictor Regulates Spermatogenesis by Controlling Sertoli Cell Cytoskeletal Organization and Cell Polarity in the Mouse Testis.(雷帕霉素靶蛋白不敏感組分(Rictor)通過控制小鼠睪丸支持細胞骨架的組織和細胞極性調節精子發生)
84.Oncotarget, 2015 April 20. Macrophages promote benzopyrene-induced tumor transformation of human bronchial epithelial cells by activation of NF-κB and STAT3 signaling in a bionic airway chip culture and in animal models.（巨噬細胞通過在仿生氣道芯片培養和動物模型的κB和STAT3信號通路的活化從而促進苯并芘誘導的人支氣管上皮細胞腫瘤的轉化）(IF:5.168 )
85.Hepatology, 2015 JUL 3. MicroRNA-125b attenuates epithelial-mesenchymal transitions and targets stem-like liver cancer cells through small mothers against decapentaplegic 2 and 4.(（MicroRNA-125b通過small mothers減少Dpp2和4以減弱上皮細胞-間充質細胞轉化并作用于肝癌細胞干細胞）(IF: 11.711.)
86.Critical Care Medicine, 2015, June 27. Cyclophilin A/Cluster of Differentiation 147 Interactions Participate in Early Brain Injury After Subarachnoid Hemorrhage in Rats.(大鼠蛛網膜下腔出血早期親環蛋白A/CD147相互作用)(IF: 7.422.)
87.Cellular and Molecular Life Sciences, 2015 June 26. Rab5-mediated VE-cadherin internalization regulates the barrier function of the lung microvascular endothelium.(肺微血管內皮細胞)(IF: 5.808.)
88.Graefes Arch Clin Exp Ophthalmol, 2015 May 31. Effects of CD25siRNAgene transfer on high-risk rat corneal graft rejection.(高危大鼠角膜移植片排斥中CD25siRNA基因轉移作用)
89.Brain behavior and immunity, 2015 April 29. MicroRNA let-7c-5p protects against cerebral ischemia injury via mechanisms involving the inhibition of microglia activation.(MicroRNA let-7c-5p通過抑制小膠質細胞活化防止腦缺血損傷) (IF: 5.889.)
90.Basic Research in Cardiology, 2015 April 10, 110:28. Sialyltransferase7A, a Klf4-responsive gene, promotes cardiomyocyte apoptosis during myocardial infarction.(Sialyltransferase7A，一個Klf4的應答基因，在心肌梗死中促進心肌細胞凋亡)(IF: 6.038.)
91.Plos one, 2015 March 20. ENTPD5 Induces Apoptosis in Lung Cancer Cells via Regulating Caspase 3 Expression.(ENTPD5通過調控Caspase 3表達誘導肺癌細胞凋亡)
92.Experimental Biology and medicine, 2015 Mar 13. Mechanism of programmed cell death factor 4/nuclear factor-κB signaling pathway in porcine coronary micro-embolization-induced cardiac dysfunction.(細胞死亡因子4/NF-κB在豬冠狀動脈微栓塞引起的心臟功能障礙中的發生機制)
93.J Neuroinflammation, 2015 Jan 28. NLRP1 inflammasome is activated in patients with medial temporal lobe epilepsy and contributes to neuronal pyroptosis in amygdala kindling-induced rat model.(NLRP1炎性體在內側顳葉癲癇患者中被激活并能促進在杏仁核刺激的大鼠模型的神經元細胞死亡)(IF: 5.408.)
94.Journal of Neuroimmunology, 2013 Oct 8.MicroRNA-155 Modulates Th1 and Th17 Cell Differentiation and is Associated with Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis.(注射miRNA研究對免疫疾病的作用機理)
95.Cancer Res. 2015 Jan 19. pii: canres.1831.2014.Targeting LunX inhibits non-small-cell lung cancer growth and metastasis.(IF: 9.329.) (肺癌)
96.Endocrine. 2015 Feb 11.MiR-346 regulates CD4+CXCR5 + T cells in the pathogenesis of Graves’ disease.(甲狀腺)
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98.Biomed Res Int. 2014;2014:898646.Trichinella spiralis excretory-secretory products protect against polymicrobial sepsis by suppressing MyD88 via mannose receptor.(免疫系統)
99.Mol Cancer. 2014 Sep 6;13(1):206.Let-7d suppresses growth, metastasis, and tumor macrophage infiltration in renal cell carcinoma by targeting COL3A1 and CCL7.(IF:5.683.)(腫瘤相關研究)
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101.Neurosci Lett. 2014 Mar 11.Autophagic effect of programmed cell death 5 (PDCD5) after focal cerebral ischemic reperfusion injury in rats.(凋亡相關研究)
102.Mol Immunol. 2014 Jan 21;59(1):30-38.Inhibition of IL-2 inducible T-cell kinase alleviates T-cell activation and murine myocardial inflammation associated with CVB3 infection.(心臟疾病)
103.J Biol Chem. 2013 Oct 7.Heme Oxygenase-1 Exerts a Protective Role in Ovalbumin-induced Neutrophilic Airway Inflammation by Inhibiting Response in the Immune Cells Th17.(肺過敏性哮喘)
104.Journal of Neuroimmunology. 2013 Oct 8.MicroRNA-155 Modulates Th1 and Th17 Cell Differentiation and is Associated with Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis.(注射miRNA研究對免疫疾病的作用機理)
105.Journal of Alzheimer’s disease.2013 Sep 18.IL12/23 p40 Inhibition Ameliorates Alzheimer’s Disease-Associated Neuropathology and Spatial Memory in SAMP8 Mice.(腦室注射siRNA研究對阿耳茨海默氏病的治療)
106.Purinergic Signal. 2013 Jun 11.Sensory-sympathetic coupling in superior cervical ganglia after myocardial ischemic injury facilitates sympathoexcitatory action via P2X7 receptor.(舌下靜脈注射siRNA干擾脊神經背根神經節受體)
107.CNS Neurosci Ther. 2013 May 3.The Involvement of Programmed Cell Death 5 (PDCD5) in the Regulation of Apoptosis in Cerebral Ischemia/Reperfusion Injury.(腦室注射siRNA研究腦缺血的凋亡機理)
108.Matrix Biol. 2013 Mar 5.Transdermal siRNA-TGFβ1-337 patch for hypertrophic scar treatment.(IF:5.074.)(皮膚涂抹siRNA研究治療皮膚瘢痕)
109.J Cereb Blood Flow Metab. 2013 Jan 9.SirT1 mediates hyperbaric oxygen preconditioning-induced ischemic tolerance in rat brain.(IF:5.407.) (腦室注射siRNA研究腦缺血機理)
110.Cancer Lett. 2012 Jan 28;314(2):223-31. Epub 2011 Oct 5.NIRF is frequently upregulated in colorectal cancer and its oncogenicity can be suppressed by let-7a microRNA.(IF:5.621.)(皮下腫瘤注射miRNA研究治療結腸癌)
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相關資料
●轉基因動物，基因敲除動物和體內轉染的比較
●EntransterTM-in vivo體內轉染和病毒體內轉染的比較
●EntransterTM-in vivo使用手冊
相關問題
●小鼠尾靜脈注射技巧?
●體內轉染需要的條件?
●轉染試劑和核酸需要多少?
●試劑在體內的分布？
●試劑作用的原理？
●如何檢測效果？
運輸與儲存
常溫運輸，儲存于4℃。
安全性
本品使用安全，未發現任何生物、化學毒性。如不慎沾染，用清水沖洗即可。
